Diosmetin (Dios), a flavone aglycone, is a major active ingredient of many herbal medicines.
Previous studies implicated that the potential antitumor activities of Dios are mediated through
multiple cell signaling pathways, however more investigations are required to reveal the targets and
mechanisms of Dios. In this study, our results demonstrated that cell cycle progression and proliferation
of HepG2 cells were inhibited by Dios. Meanwhile, Dios-induced liver cancer cell apoptosis was
related with the p53 activation. After PFT-α, a p53 inhibitor was added into Dios-treated HepG2
cells, cell growth inhibition was partially reversed. These findings defined and supported that p53 is
a novel target of Dios. By activating p53, Dios exerts anticancer effects by inducing cell cycle arrest
and apoptosis in HepG2 cells.
Keywords: Diosmetin, HepG2, P53, apoptosis, flavonoids, ERK and JNK phosphorylation.
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