Background: Pyrrolidine-based ring systems are ubiquitous in nature. (R)-Bgugaine is a
2-alkylated pyrrolidine alkaloid which has been isolated from the tubers of Arisarum vulgare, a toxic
Araceae found along the Mediterranean coast. The construction of this heterocyclic ring system in an
enantio-riched fashion has been the subject of attention in the recent years. This article covers the reports
till 2016 on the isolation, biological activity studies and synthetic endeavours of bgugaine alkaloid.
Method: The synthesis of (R)-Bgugaine was carried out. A structured search of Bgugaine was undertaken
using bibliographic databases such as scifinder, scopus etc. The quality of the collected papers
was evaluated using the impact factor (SCI) of journals in which the work was reported. The synthetic
methodologies and chemical reactions from the screened papers were summarised wherein, the key reaction
steps have been described in detail.
Results: Thirty seven papers were summarized in the review to give snapshots of natural product i.e.
bgugaine. The majority (20) articles focused on the introduction of the topic. These papers were published
from different research groups working world-wide in the field of alkaloids chemistry. The general
information about alkaloids, their medicinal uses, biological activity and structural elucidation
comprises the highlights of this section. This demonstrates the importance of collaboration of experts
working in multidisciplinary area to understand the topic in depth. Eight articles are corresponding to
the synthetic protocol for construction of bgugaine via multistep synthesis. Remaining nine articles are
citing the important reactions which are used as key steps for synthesis of bgugaine. Overall, this review
has identified the scope and significance of collaboration between synthetic, medicinal, biochemists
and natural product chemists to identify bioactive compounds showing drug-like properties.
Conclusion: The findings and content of this review give explicit information regarding the importance
of deceptively simple pyrrolidine alkaloid skeleton, their natural occurrence, biological activities
as well as synthetic methodologies. The advancement of new methodologies towards the construction
of bgugaine could be useful for rapid identification of new biological leads. It shall certainly be of help
to make further progress and develop new strategies for bgugaine core and related heterocycles, based
on this literature report.