Advances in Modern Medicine

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Advances in Modern Medicine introduces recent advanced medical practices performed at the Kure Medical Center and Chugoku Cancer Center (KMCCCC) - one of the leading hospitals in Japan - to those ...
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Late Endocrine Effect for Childhood Cancer Survivors

Pp. 160-166 (7)

Shinichiro Miyagawa


In recent years, the treatment and diagnosis of childhood cancer has led to dramatic improvements in survival rates. Approximately, 75-80% of affected children survived a malignant disease. However, the improvement in prognosis has been achieved at the expense of serious late effects from cancer and cancer treatment. Endocrinological late effects are the most common problem and were found in approximately 20-30% of child cancer survivors (CCSs). Endocrinologists should participate in the follow-up of CCSs in collaboration with pediatric oncologists. Further, long-term follow up is necessary for CCSs because treatment-related complications may occur during childhood and many years after therapy.


Child cancer survivors, Growth impairment, Late effect, Malignant disease, Treatment.


Department of Pediatrics, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0023, Japan.