Background: The higher risk of diabetic nephropathy (DN) leads to end stage
renal diseases worldwide, which is associated with chronic inflammation. Currently, the
available treatments are limited, lack of efficacy and safety. Therefore, we are in need of
novel targets and advanced treatments to reduce the necessity for the renal replacement
therapy and burden of this disease management.
Object/Methods: In this review, we performed through an inflammatory mechanism that
contribute to DN, will provide a key point to the finding off novel therapeutic agents. In addition,
we discuss the current anti-inflammatory drugs, an alternative approach of seaweed
polysaccharides and also exploring the future perspective of anti-inflammatory natural seaweed
compounds. Currently, seaweeds are taking majority of attention from scientists for
targeting the various diseases. This will become a more significant part of the pipeline and
alternate medicines for anti-inflammatory and chronic diseases.
Conclusion: The potential benefits of natural seaweed novel compounds in inhibiting inflammatory
pathways would be useful for the prevention of diabetic nephropathy. Thus, this
therapy manifests the clinical benefits of these compounds in the near future.