Frontiers in Parasitology

Frontiers in Parasitology

Volume: 1

Molecular and Cellular Biology of Pathogenic Trypanosomatids

Indexed in: EBSCO.

Frontiers in Parasitology is an Ebook series devoted to publishing the latest and the most important advances in parasitology. Eminent scientists present reviews on the microbiology, cytology, ...
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The Cellular Organization of Trypanosomatids During Life Cycle

Pp. 3-60 (58)

Simone Guedes Calderano, Nilmar Silvio Moretti, Christiane Araujo, Marcelo S. da Silva, Teresa Cristina Leandro de Jesus, Loyze P. Oliveira de Lima, Mariana de Camargo Lopes, Leonardo da Silva Augusto, Julia Pinheiro Chagas da Cunha, Maria Carolina Elias and Sergio Schenkman


Trypanosoma cruzi , Trypanosoma brucei and Leishmania spp. are etiological agents of the following neglected diseases: African sleeping sickness (T. brucei ), Chagas’ disease (T. cruzi ) and leishmaniasis (Leishmania spp.). These parasites are eukaryotic cells that diverged early in evolution and therefore harbor modified organelles, such as glycosomes, and present subcellular compartments with unusual characteristics. This chapter aims to overview the most striking features of the structures and functions of these organelles, which ensure the existence of these parasites, and to discuss the differences between species and between the distinct life cycle forms of each organism.


Acidocalcisomes, Cellular compartmentalization, Endoplasmic reticulum, Flagellum, Glycosomes, Golgi, Kinetoplast, Nucleolus, Nucleus, Reservosomes.


Universidade Federal de São Paulo, Brazil.