The Cellular Organization of Trypanosomatids During Life Cycle
Pp. 3-60 (58)
Simone Guedes Calderano, Nilmar Silvio Moretti, Christiane Araujo, Marcelo S. da Silva, Teresa Cristina Leandro de Jesus, Loyze P. Oliveira de Lima, Mariana de Camargo Lopes, Leonardo da Silva Augusto, Julia Pinheiro Chagas da Cunha, Maria Carolina Elias and Sergio Schenkman
Trypanosoma cruzi , Trypanosoma brucei and Leishmania spp. are
etiological agents of the following neglected diseases: African sleeping sickness (T.
brucei ), Chagas’ disease (T. cruzi ) and leishmaniasis (Leishmania spp.). These
parasites are eukaryotic cells that diverged early in evolution and therefore harbor
modified organelles, such as glycosomes, and present subcellular compartments with
unusual characteristics. This chapter aims to overview the most striking features of the
structures and functions of these organelles, which ensure the existence of these
parasites, and to discuss the differences between species and between the distinct life
cycle forms of each organism.
Acidocalcisomes, Cellular compartmentalization, Endoplasmic reticulum, Flagellum, Glycosomes, Golgi, Kinetoplast, Nucleolus, Nucleus, Reservosomes.
Universidade Federal de São Paulo, Brazil.