Oral Colonization by Nosocomial Pathogens During Hospitalization in Intensive Care Unit and Prevention Strategies

Author(s): Hossein Kazemian, Samane Bourbour, Maryam Beheshti, Abbas Bahador*

Journal Name: Recent Patents on Anti-Infective Drug Discovery
Continued as Recent Advances in Anti-Infective Drug Discovery

Volume 12 , Issue 1 , 2017

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Graphical Abstract:


Background: Critically ill patients are very susceptible to a variety of disorders and infections during hospitalization in Intensive Care Units [ICU]. Among these problems, nosocomial infections are major causes of morbidity and mortality.

Methods: Nosocomial pneumonias, specifically ventilator associated pneumonias have become a major health care issue. The implication of oral care in hospital presents challenges that can prevent or reduce the risk of nosocomial pneumonias in ICU. In this review article, we reviewed the most important nosocomial pathogens which colonize the oral cavity and causes severe infections during hospitalization in ICU.

Conclusion: Finally, we discuss that the prevention strategies against oral colonization of nosocomial pathogens include classical methods and novel methods such as Photodynamic therapy, NO based therapy, anti-virulence therapy and other new under investigation antimicrobial strategies.

Keywords: Critically ill patients, nosocomial infection, ICU, oral colonization, Staphylococcus aureus, probiotics.

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Article Details

Year: 2017
Published on: 15 February, 2017
Page: [8 - 20]
Pages: 13
DOI: 10.2174/1574891X12666170215152854
Price: $65

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PDF: 55