Cell-based tolerogenic therapy is a promising approach for the treatment of autoimmune diseases and
transplant rejection. Regulatory T cells and tolerogenic dendritic cells have been particularly explored in the
treatment of various autoimmune disorders in experimental models of disease. Although some of these cells have
already been tested in a limited number of clinical trials, there is still a need for preclinical research on tolerogenic
cells in animal models of autoimmunity. This review will focus on the relevance of data obtained from
studies in experimental animal models for the use of tolerogenic cell-based therapy in humans. Also, perspectives
for further improvement of tolerogenic cell preparation towards enhanced suppressive activity and stability of the
cells will be discussed.
Keywords: Cell-based tolerogenic therapy, regulatory T cells, tolerogenic dendritic cells, multiple sclerosis, type 1 diabetes, rheumatoid arthritis.
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