Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

Title:Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

Volume: 15 Issue: 3

Author(s): Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie

Affiliation:

• Dipartimento di Farmacia, Universita di Chieti-Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100 Chieti,Italy

Keywords: AMPs, peptides, lysine- and arginine-rich peptides, Candida spp., multi-drug resistance, microorganisms.

Abstract: Background: In recent years, the multi-drug resistance of bacteria and fungi strains has become a worldwide problem. The incidence of fungal and bacterial infections is experiencing a serious growth and the microorganisms have developed several new mechanisms of antibiotic resistance.

Methods: Antimicrobial peptides (AMPs) constitute one of the well-known barrier defense systems of plants. They have been isolated from roots, seeds, flowers, stems and leaves of a wide variety of species and have activities towards phytopathogens, as well as against human pathogens. AMPs are often cationic peptides able to interact with the membrane through penetration or dissolving the biofilms.

Results and Conclusion: In this paper, we report the synthesis of several arginine and lysine-rich peptides and their evaluation as antimicrobial agents.

Cite this article as:

Mollica Adriano*, Macedonio Giorgia, Stefanucci Azzurra, Costante Roberto, Carradori Simone, Cataldi Valentina, Giulio Di Mara, Cellini Luigina, Silvestri Romano, Giordano Cesare, Scipioni Anita, Morosetti Stefano , Punzi Pasqualina and Mirzaie Sako, Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity, Letters in Drug Design & Discovery 2018; 15 (3) . https://dx.doi.org/10.2174/1570180814666170213161341