Introduction: Stryphnodendron rotundifolium Mart. is a native specie of the “Cerrado”
area of Northeast Brazil and is used in traditional communities for the treatment of inflammation,
infection, gastritis and other diseases.
Objective: We evaluated the gastroprotective effect of the hydroalcoholic extract of Stryphnodendron
rotundifolium Mart. (HESR) in animal models of classic gastric lesions, the mechanism of
action and its effect on intestinal motility.
Methods: Phytochemical prospecting is a procedure by qualitative and HPLC-DAD method. The
in vivo assay was evaluated by classical methods of gastric lesion and intestinal motility.
Results: HESR showed a significant gastroprotective effect without altering the intestinal motility
of mice. Furthermore, the effect of HESR was significantly reduced in mice pretreated with
L-NAME and endogenous prostaglandins, the respective inhibitors of nitric oxide synthase and
Conclusion: The data provides evidence to show that HESR provides gastroprotection against
gastric damage induced by ethanol, acidified ethanol and indomethacin. The mechanism
away showed involvement of endogenous prostaglandins, nitric oxide release, the activation of
TRPV1 receptor and ATP-sensitive K+ channels and significant action in the reduction of intestinal
motility. This result represents a promising source of natural pharmacological therapies or treatments
of gastric diseases.