Background: The Carrier linked prodrug as per literature is known to be a
pharmacologically inactive chemical derivative and could be used to change the
physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and
consist of two usually synergistic drugs or moieties attached to each other.
Objective: synthesis of codrug consists of two pharmacologically active compounds
coupled together where one drug is the carrier for the other and vice versa.
Result: It is a very beneficial area of research and its admittance in human therapy has
given successful results clinically as well as therapeutically.
Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol
for improved anti-inflammatory and analgesic activity. The article also takes a review of the
various applications of Codrugs and the development in this field during the last few decades.