Prodrugs to Codrugs

Author(s): Deepali Gangrade*, Ravindra Karande

Journal Name: Current Drug Therapy

Volume 12 , Issue 1 , 2017

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Graphical Abstract:


Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other.

Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa.

Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically.

Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades.

Keywords: Prodrugs, codrugs, carrier linked prodrugs, spacer, benorylate.

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Article Details

Year: 2017
Page: [29 - 36]
Pages: 8
DOI: 10.2174/1573413713666170210095211
Price: $65

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PDF: 19