Background: IBD is considered as one of the major public health concerns worldwide. The pathophysiology
and gut microbial alteration during inflammatory bowel disease (IBD) are still not completely understood.
Gut microbiota is implicated in most of the gastro-intestinal (GI) diseases including IBD. From the time of
gut microbiota establishment and through aging, it undergoes a lot of changes in the composition.
Methods: In a healthy state, the composition of beneficial microbes in the gut is comparatively higher and due to
factors such as malnutrition, use of antibiotics and any underlying diseases allow the colonization and invasion of
Results: A careful manipulation of gut microbiota during disease conditions such as IBD is required. Probiotics
are natural, safe and useful interventions for GI diseases.
Conclusion: Lactic acid probiotic bacteria have shown many beneficial effects in various gastrointestinal and
inflammatory disorders. This review focuses on the use of probiotics in IBD and possible mechanism of probiotics
in inflammation conditions.