Title:A New Approach for Skin-Derived Precursors to Ameliorate Skin Photodamage Through Activation of Nrf2 Signaling Pathway
VOLUME: 12 ISSUE: 1
Author(s):Dehai Xian, Jianqiao Zhong* and Xiaoqing Gao
Affiliation:Department of Human Anatomy, Southwest Medical University, Luzhou 646000, Department of Dermatology, Affiliated Hospital of Southwest Medical University, No. 25 Tai Ping Jie, Luzhou, Sichuan 646000, Department of Neurobiology, Southwest Medical University, Luzhou 646000
Keywords:Skin photodamage, skin-derived precursor cells (SKPs), NF-E2-related factor 2 (Nrf2), reactive oxygen species
(ROS), ultraviolet (UV), oxidative stress, stem cells.
Abstract:Background: Skin photodamage exhibits poorly clinical efficacy and so far has rarely
satisfactory treatments. Ultraviolet (UV)-induced overproduction of reactive oxygen species (ROS),
NF-E2-related factor 2 (Nrf2) inactivation and Nrf2/antioxidant response elements (ARE) signaling
pathway blockage play important roles in skin photodamage pathogenesis. Skin-derived precursor cells
(SKPs), a population of dermal stem cells, are predominant over wound repair and skin regeneration.
Objective: To hypothesize that SKPs are useful in skin photodamage by Nrf2 activation.
Methods: Published papers on skin photodamage and SKPs were collected and reviewed. Besides, the
findings from our preliminary experiment were reported in this article.
Results: It has been confirmed that stem cells could participate in tissue repair via activating Nrf2 and
Nrf2/ARE signal transduction pathway. Furthermore, our previous and current outcomes revealed that
SKPs could ameliorate UVB-induced apoptosis or damage and significantly up-regulate Nrf2
expression after UV irradiation.
Conclusion: Together the above data, we speculate that SKPs may be good candidates for control of
skin photodamage through activating Nrf2 and its signaling pathway. These would provide a new
approach for resisting skin photodamage.
