Background: Thyroid hormone (T3) is essential for normal development of children enabling brain
development and somatic growth. However, certain individuals are genetically predisposed with insufficient or no
thyroid hormones. Such a condition is termed congenital hypothyroidism (CH).
Objective: In the present review, a brief back ground about congenital hypothyroidism, factors associated with
CH leading to thyroid dysgenesis and thyroid dyshormonogenesis is elaborated. Additionally, the guidelines for
available treatment options, management and follow-up required for patients diagnosed with CH are discussed.
Treatment options in terms of treatment initiation and dosage of hormone replacement are discussed.
Conclusion: Though CH is considered as the most common neonatal metabolic disorder, it is also easily treatable
compared to other metabolic or hereditary diseases. The outcome of CH treatment depends on the compliance of
parents early in life and by patients themselves during later part of life.