The design and fabrication of transdermal system is an art. Out of many transdermal systems,
the introduction of Drug-in-adhesive drug delivery executes close contact of the carrier with stratum
corneum to deliver active molecules across the skin and then into the systemic circulation. Thus, aspect
of adhesives in transdermal is vital parameter for fabrication design with respect to safety, efficacy and
quality of transdermal drug delivery system. Drug-in-adhesive transdermal patch, prevents partial loss
of active drug during process involved in manufacturing and drying of the patches. The optimization of
the adhesive properties exhibits an important challenge during pharmaceutical development on the side
of minimizing the uncertainty of adhesion failure in practice. This article provides groundwork for understanding
general properties of pressure sensitive adhesives (PSA) and utilization in the development
of transdermal patches. The manuscript summarizes most extensive methods to measure adhesive properties
in the time of development studies.
Keywords: Drug-in-adhesive, pressure sensitive adhesives, rheology, transdermal, viscoelastic.
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