Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis

Author(s): Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo*

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 15 , Issue 1 , 2017

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Graphical Abstract:


Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations.

Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.

Keywords: Pernicious anemia, pathophysiology, diagnostic challenges, fundamental aspects, practical approach, cobalamia deficiency.

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Article Details

Year: 2017
Page: [17 - 22]
Pages: 6
DOI: 10.2174/1871525715666170203114632
Price: $65

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PDF: 81
PRC: 2