Abstract
Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations.
Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.
Keywords: Pernicious anemia, pathophysiology, diagnostic challenges, fundamental aspects, practical approach, cobalamia deficiency.
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis
Volume: 15 Issue: 1
Author(s): Aung Myint Tun, Kyaw Zin Thein, Zin War Myint and Thein Hlaing Oo*
Affiliation:
- The University of Texas M.D. Anderson Cancer Center, Section of Thrombosis & Benign Hematology (Unit 1464), 1515 Holcombe Blvd., Houston, TX 77030,United States
Keywords: Pernicious anemia, pathophysiology, diagnostic challenges, fundamental aspects, practical approach, cobalamia deficiency.
Abstract: Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations.
Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.
Export Options
About this article
Cite this article as:
Tun Myint Aung, Thein Zin Kyaw, Myint War Zin and Oo Hlaing Thein*, Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis, Cardiovascular & Hematological Agents in Medicinal Chemistry 2017; 15 (1) . https://dx.doi.org/10.2174/1871525715666170203114632
DOI https://dx.doi.org/10.2174/1871525715666170203114632 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
Call for Papers in Thematic Issues
Medicinal Plants with Beneficial Properties on Diabetes and Hypertension
Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Crystallization and Preliminary X-Ray Studies of the Fab Fragment from a Humanized Version of the Mouse Anti-Human Fas Antibody Hfe7a
Protein & Peptide Letters Vitamin D : Autoimmunity and Gender
Current Medicinal Chemistry Myelin Sheaths and Autoimmune Response Induced by Myelin Proteins and Alphaviruses. I. Physicochemical Background
Current Medicinal Chemistry Role of Leptin in the Immune System
Current Immunology Reviews (Discontinued) The Study of HLA Class II and Autoimmune Diabetes
Current Molecular Medicine Small Molecule Inhibitors of Phosphoinositide 3-Kinase (PI3K) δ and γ
Current Topics in Medicinal Chemistry Methotrexate: A Drug of the Future in Ulcerative Colitis?
Current Drug Targets Regulatory T Cells in Severe Drug Eruptions
Current Immunology Reviews (Discontinued) Sjogrens Syndrome and Lymphoma Development
Current Immunology Reviews (Discontinued) Impact of Hydroxyl Radical Modified-Human Serum Albumin Autoantigens in Systemic Lupus Erythematosus
Current Protein & Peptide Science JAK3 Inhibitors in Organ Transplantation and Autoimmune Disease
Recent Patents on Inflammation & Allergy Drug Discovery Control of Autoimmune Diseases by the B7-CD28 Family Molecules
Current Pharmaceutical Design NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives
Current Drug Targets Role of Glucocorticoids in Breast Cancer
Current Pharmaceutical Design Vasculitis Following Influenza Vaccination: A Review of the Literature
Current Rheumatology Reviews T Cell-Activated Signaling Pathways and Locally Produced Cytokines as Potential Targets in Celiac Disease
Current Drug Targets Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles,Pathophysiology and Therapeutic Choices
Current Neuropharmacology S1P Receptor Modulators in Cell Trafficking and Therapeutics
Current Immunology Reviews (Discontinued) Mechanisms of Neutrophil-mediated Disease: Innovative Therapeutic Interventions
Current Pharmaceutical Design Immunomodulatory Activity of Mesenchymal Stem Cells
Current Stem Cell Research & Therapy