Challenges with Mosquito-borne Viral Diseases: Outbreak of the Monsters

Author(s): Renu Gautam, Sweta Mishra, Archana Milhotra, Ritika Nagpal, Mradul Mohan, Anchal Singhal, Pratibha Kumari*

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 19 , 2017


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Abstract:

Background: The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day. Zika virus may damage brain by targeting the neuron cells in babies, and thereby it is very perilous to pregnant women.

Dangerous Type: A less common but highly dangerous type of dengue is one which causes haemorrhagic fever and shock syndrome which are lethal. Chikungunya is not as lethal as Zika and dengue are, but it triggers joints pain which could last for months and even for years.

Conclusion: The vaccines against Zika, dengue and chikungunya viruses are at different stages of development. The challenges associated with the epidemic wave of Zika, dengue and chikungunya viruses have been explained and the current status of drug/ vaccine development against these viruses has been reviewed.

Keywords: Mosquito-borne diseases, Viral diseases, Zika, Dengue, Chikungunya, Vaccine.

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Article Details

VOLUME: 17
ISSUE: 19
Year: 2017
Published on: 15 June, 2017
Page: [2199 - 2214]
Pages: 16
DOI: 10.2174/1568026617666170130122921
Price: $65

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