Title:Application of 3-methylene- and 3-(monosubstituted)alkylideneoxindoles in the Synthesis of Heterocyclic Compounds
VOLUME: 21 ISSUE: 14
Author(s):Abdolali Alizadeh*, Fahimeh Bayat and Leila Moafi
Affiliation:Department of Chemistry, School of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran, Department of Chemistry, School of Sciences, Tarbiat Modares University, Tehran, Department of Chemistry, School of Sciences, Tarbiat Modares University, Tehran
Keywords:Oxindoles, 3-(monosubstituted)alkylideneoxindoles, spirooxindole, biological activity, Michael addition, Diels-Alder reaction,
heterocycles.
Abstract:3-(Monosubstituted)alkylideneoxindoles as one major part of the oxindoles are involved in many
essential biologically active compounds, like as self-germination and tyrosine kinase inhibitors. They have
been extensively used as starting materials for the synthesis of a large number of different heterocycles. The
aim of this review is to give an overview of diverse methodologies that have been developed for the construction
of 3-methylene and 3-(monosubstituted)alkylideneoxindoles and their utility in organic synthesis, highlighting
the variety of compounds that can be directly accessed from single reactions over these systems and
emphasizing the influence of the reaction conditions in the outcome of the transformations. The reactions are
classified into three main categories: one-component, two-component, and multicomponent reactions.
