Comparison of Biolimus Versus Everolimus for Drug-Eluting Stents in the Percutaneous Treatment of Infra-Inguinal Arterial Disease

Author(s): Arturo Giordano, Paolo Ferraro, Nicola Corcione, Stefano Messina, Gennaro Maresca, Enrico Coscioni, Raffaella Avellino, Gabriele Giordano, Mariangela Peruzzi, Antonino G. M. Marullo, Giovanni Napolitano, Maria Fiammetta Romano*, Giuseppe Biondi-Zoccai

Journal Name: Current Vascular Pharmacology

Volume 15 , Issue 3 , 2017

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Abstract:

Background: Drug-eluting stents (DES) are now considered the most promising device to treat peripheral artery disease (PAD) and minimize restenosis. There is uncertainty however on the best antirestenotic drug for such devices. In particular, biolimus (i.e. umirolimus) and everolimus are two of the most promising agents, given the extensive data in support of their coronary safety and efficacy, but their comparative effectiveness for peripheral interventions is not established.

Methods: Building upon our extensive experience in the percutaneous treatment of infra-inguinal artery disease with DES, we compared the acute and longterm outlook of patients treated with biolimus-eluting stents (BES) and everolimus-eluting stents (EES). We collected baseline, procedural and outcome details on all patients undergoing infra-inguinal BES or EES implantation. The endpoints of interest were death, amputation, revascularization, their composite, and change in Fontaine class. A total of 80 patients were included (20 treated with BES and 60 with EES). Most features were similar in the two groups, despite longer lesions in the EES group. Unadjusted analysis showed similar results irrespective of the drug used, with composite endpoint occurring, respectively, in 4 (20.0%) and 10 (16.7%) (p=0.741).

Results and Conclusion: However, analysis with inverse probability of treatment weighting showed significant differences in the risk of revascularization (hazard ratio of BES vs EES=9.55 [95% confidence interval 2.16-42.23], p=0.003) and composite endpoint (hazard ratio=5.11 [1.33-19.62], p=0.018). In conclusion, EES appear superior to BES for endovascular therapy of infrainguinal artery disease. Dedicated randomized trials are required to definitely confirm or disprove these findings.

Keywords: Biolimus, drug-eluting stent, everolimus, peripheral artery disease, popliteal artery, stent, superficial femoral artery, umirolimus.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2017
Page: [257 - 264]
Pages: 8
DOI: 10.2174/1570161115666170123094523
Price: $65

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