Association of Folate Level in Blood with the Risk of Schizophrenia

Author(s): Yujie Ding, Mingliang Ju, Lin He, Wenzhong Chen*

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 20 , Issue 2 , 2017

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Aim and Objective: The aim of this study was to evaluate the association between folate level and the risk of schizophrenia and to identify possible biomarker for schizophrenia.

Materials and Methods: Data about folate were extracted from 16 high quality studies. The association of folate level in blood and schizophrenia was evaluated using standardized mean difference (SMD) and 95% confidence interval (CI).

Results: Totally 1183 (52.1%) cases and 1089 (47.9%) controls were included in the current metaanalysis. Folate level in schizophrenia patients was significantly lower than that in healthy controls (SMD= −0.65; 95% CI: [−0.86, −0.45]; P <0.00001). Subgroup analysis demonstrated that the decreased folate level was found in both Asian and European patients (SMD=−0.86, P<0.00001; SMD=−0.44, P<0.00001, respectively), while there were no significant differences in patients from other areas (P>0.05). Sensitivity analysis confirmed that these results were stable and reliable, no publication bias existed in our meta-analysis based on Egger's and Begg's tests (P=0.48 and 0.30, respectively).

Conclusion: These results suggest that decreased folate may be a risk factor for schizophrenia. More epidemiological and biochemistry studies are required to describe how folate or folate supplementation play roles in the progress of schizophrenia.

Keywords: Folate, schizophrenia, meta-analysis, case-control study, folic acid, neurodevelopmental disorders.

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Article Details

Year: 2017
Page: [116 - 122]
Pages: 7
DOI: 10.2174/1386207320666170117120828
Price: $65

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