Background: Traumatic brain injury (TBI) is the result of an external physical force to the head that
harms the brain. TBI is a major public health problem worldwide and mainly results from falls, vehicle accidents
Clinical problem: The management of TBI, causing a wide spectrum of possible health outcomes, has barely
changed over the years as encouraging outcomes from many pre-clinical therapeutic and pharmacological studies
have only rarely been translated to the clinical situation.
New management options: In the last decades management of TBI is rapidly advancing and new innovative
imaging modalities with sophisticated treatment options by using nanomedicine based drug delivery systems are
under investigation. Nano formulations such as PLGA, exosomes and liposomes have the advantage of a targeted
and controlled delivery of their cargo, such as diagnostic probes and/or therapeutic drugs.
Summary: Here we provide an overview of new promising pre-clinical developments in TBI management that
may find their way to the clinic in the near future. Nanotechnology and nanomedicine in TBI intervention may
establish new platforms for targeted drug delivery to the traumatized brain to improve the quality of life and survival
of TBI patients.