Sonication-assisted nanoprecipitation provides an effective tool for nanomedicine engineering in therapeutic
improvement. In the scope of this review, original works in interdisciplinary areas of using sonication with precipitation
method for nanoparticulate drug delivery systems and its applications in management of different diseases are
discussed. The use of sonication-assisted nanoprecipitation has been proved to improve drug bioavailability, which
attracts tremendous interests as an effective strategy for drug delivery. However, many challenges still remain. To
overcome these barriers, different approaches such as precipitation method, rational design, optimization and modification
have been investigated. Accordingly, current knowledge of sonication-assisted nanoprecipitation proposes a broad
perspective and optimization for the applications of nanotechnology in drug delivery.