Background: The amine (2) was prepared starting from 1-(4-fluorophenyl) piperazine via
two steps, and then converted to the corresponding hydrazide (4). The reaction of hydrazide (4) with
carbon disulfide generated the corresponding 1,3,4-oxadiazole (5), while the treatment of hydrazide
with ethyl bromoacetate produced 4-oxo-2-thioxo-1,3-thiazolidine compound (6). The fourcomponent
condensation of 4 with several aldehydes gave the corresponding 4-oxo-2-thioxo-1,3-
: The synthesis of 4-oxo-1,3-oxazolidines (9a,b)
, 1,3-oxazoles (10a,b)
was carried out starting from compounds 8a,b.
Mannich bases (12a-d and 13a-f)
prepared using three component condensation of compounds 5 and 12a,b and corresponding amines.
The synthesis of 16a-c
, which were considered as the new analogues of azole class antifungals, was
performed starting from the compound 14a
via three steps.
Results and Conclusion
: All the reactions were examined under traditional and microwave
irradiation conditions, and optimum conditions were defined. The antimicrobial activities of the
newly synthesized compounds were screened and some of the tested compounds were displayed
good-moderate antibacterial activity.