Background: Despite recent advances in improved glycemic control, the magnitude of lifetime
risk from premature cardiovascular disease in individuals with type 1 diabetes remains at least 10
fold higher than in the general population. The availability of lipoprotein fractionation has allowed the
spotlight for this increased risk to shift from dysglycemia to diabetes-induced dyslipidemia associated
with insulin resistance. Interventions designed to simultaneously improve both factors can have distinct
and additive effects on slowing the initiation and progression of atherosclerotic lesions. As fullblown
cardiovascular disease is not evident during childhood, there is a critical need to identify the
most predictable surrogate markers that could assign elevated risk, as well as the design of safe and
targeted interventions that could improve outcomes in this population.
Conclusion: This review will examine the evidence supporting the notion that cardiovascular disease
in type 1 diabetes is associated with significant insulin resistance and it begins in childhood, making it
necessary to design rational clinical trials that will significantly reduce risk in this population.
Keywords: Cardiovascular disease, dyslipidemia, HbA1c, insulin resistance, lipoproteins, statins, systematic review, type 1
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