Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy

Author(s): Cong Chen, Jianmin Wang, Xiaoyan Li, Xiaolong Liu, Xiao Han*

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 20 , Issue 5 , 2017

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Background & Aim: Photosensitizers are key molecules used in photodynamic cancer therapy (PDT), which is an effective therapeutic modality option for several diseases and nononcological disorders. Due to its lower systemic toxicity and its ability to destroy tumors selectively, PDT has been considered as clinical avenue for the treatment of several cancers.

Methods & Results: Three essential elements are involved in a PDT procedure: a photosensitizer, light of a specific wavelength, and singlet oxygen. However, the properties of conventional photosensitizers exhibit some drawbacks that may limit their use. Nanoparticles can provide significant benefits that counter these drawbacks and enable higher efficiency and biosafety. With the development of nanotechnology, nanoparticles have been used to encapsulate photosensitizers to enhance the phototoxic and pharmacokinetic properties of these agents.

Conclusion: Here, the main motivation for this review is to summarize recent progress in the development of photosensitizers, in particular, photosensitizers with nanoparticle modifications. In addition, we reviewed the clinical treatment of several diseases using photosensitizers formulated with nanoparticles, with the overall goal of aiding the design and development of novel photosensitizers.

Keywords: Photosensitizer, nanoparticle, photodynamic therapy, cancer, non-oncological disorders, clinical treatment.

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Article Details

Year: 2017
Page: [414 - 422]
Pages: 9
DOI: 10.2174/1386207320666170113123132
Price: $65

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