Background: Application of magnetic nanoparticles as a drug delivery system has attracted
great attention in the cancer therapy, interests in the pH and thermo-sensitive polymers have been increased
exponentially in biomedicine.
Objective: (N-isopropylacrylamide)-ethylene glycol dimethacrylate copolymer was coated on the surface
of Fe3O4 magnetic nanoparticles and utilized as a pH and temperature responsive nanocarrier for
encapsulation and delivery of doxorubicin, as an anti-cancer drug.
Method: First, Fe3O4 nanoparticles were prepared through the chemical co-precipitation method and
then coated by poly (N-isopropylacrylamide)-ethylene glycol dimethacrylate copolymer shell. The synthesized
nanocarrier were later used as a drug carrier for the DOX drug delivery.
Results: Nanocarriers were characterized by a number of techniques i.e. scanning electron microscopy
(SEM), dynamic light scattering (DLS(X-ray diffraction (XRD), Fourier transform infrared spectroscopy
(FT-IR), Thermo gravimetric analysis (TGA) and vibrating sample magnetometer (VSM). The effects
of pH and temperature on the drug release rate were evaluated. The obtained result revealed that
doxorubicin release rate of the polymer is temperature and pH dependent, which are desirable properties
for a selective delivery system. At the end of 72 h, only 15% of doxorubicin had been released in pH 7.4
conditions comparing to that of 58% in pH 5.8 acidic conditions at 40°C.
Conclusion: This project improves the delivery of anti-cancer drug. The preparation of this nanocarrier
was simple and fast and the prepared sorbent is biocompatible.