Title:Sumoylation in Lens Differentiation and Pathogenesis
VOLUME: 16 ISSUE: 10
Author(s):J.-W. Xiang, Z.-G. Chen, L. Gong, Y. Xiao, W.-J. Qing, L. Wang, X.-H. Hu, Z.-X. Huang, R.-L. Qi, T.-H. Yang, A.-P. Arrigo, L. Zhang, X.-C. Tang, S. Huang, F.-Y. Liu, Z.-W. Luo, Y.-F. Liu, Q. Sun, J. Gigantelli, Y.-Z. Liu and D. W.-C. Li
Affiliation:Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081
Keywords:Lens, sumoylation, differentiation, cataractogenesis, pathogenesis.
Abstract:Sumoylation, a post-translational modification discovered over a
decade ago, turns out to be a very important regulatory mechanism
mediating multiple cellular processes. Recent studies from our laboratory
and others also revealed that it plays a crucial role in regulating both
differentiation and pathogenesis of the ocular lens. This review will
summarize these progresses.
