Background: This study evaluated the biological properties of twelve 1,3-thiazolidin-4-
ones by assessing antifungal and antibacterial activities.
Methods: All compounds were tested against three fungi and two bacteria. The lowest concentration
that produced a ≥50% inhibition of the growth of yeast in comparison with positive control was
identified as MIC50
. Compound 1b showed the best antifungal result against Candida albicans
100 μg/ml (52.38% of growth inhibition). In the antifungal Rhodotorula
compounds showed good antifungal activity with MIC50
100 μg/ml (1f: 82.91% and 1i: 61.91%). For
C. parapsilosis compound 1i has MIC50
Results and Conclusion: No antibacterial activity was found for Staphylococcus aureus
at the highest concentration tested (400 μg/ml). The cytotoxicity study for three
compounds was carried out against primary astrocyte cells and no toxic effect was found at 400 μM.
This study discovered at least two potential compounds that will guide further chemical modification
to search for better results.