Antimicrobial and Cytotoxicity Activities of 2-(aryl)-3-(benzo[d][1,3] dioxol-5-yl)thiazolidin-4-ones

Title:Antimicrobial and Cytotoxicity Activities of 2-(aryl)-3-(benzo[d][1,3] dioxol-5-yl)thiazolidin-4-ones

Volume: 14 Issue: 9

Author(s): Silvana P. Souza, Hellen G. Masteloto, Daniel S. da Silva, Juliana H. Azambuja, Elizandra Braganhol, Juliana S. Ribeiro, Rafael G. Lund and Wilson Cunico*

Affiliation:

• CCQFA, Federal University of Pelotas, P.O. Box: 354, Pelotas,Brazil

Keywords: 4-thiazolidinones, 1, 3-benzodioxol, candida albicans, candida parapsilosis, rhodotorula mucilaginosa, astrocytes.

Abstract: Background: This study evaluated the biological properties of twelve 1,3-thiazolidin-4- ones by assessing antifungal and antibacterial activities.

Methods: All compounds were tested against three fungi and two bacteria. The lowest concentration that produced a ≥50% inhibition of the growth of yeast in comparison with positive control was identified as MIC₅₀. Compound 1b showed the best antifungal result against Candida albicans with MIC₅₀ 100 μg/ml (52.38% of growth inhibition). In the antifungal Rhodotorula assay, two compounds showed good antifungal activity with MIC₅₀ 100 μg/ml (1f: 82.91% and 1i: 61.91%). For C. parapsilosis compound 1i has MIC₅₀ 200 μg/ml.

Results and Conclusion: No antibacterial activity was found for Staphylococcus aureus and Escherichia coli at the highest concentration tested (400 μg/ml). The cytotoxicity study for three compounds was carried out against primary astrocyte cells and no toxic effect was found at 400 μM. This study discovered at least two potential compounds that will guide further chemical modification to search for better results.

Cite this article as:

Souza P. Silvana, Masteloto G. Hellen, da Silva S. Daniel, Azambuja H. Juliana, Braganhol Elizandra, Ribeiro S. Juliana, Lund G. Rafael and Cunico Wilson*, Antimicrobial and Cytotoxicity Activities of 2-(aryl)-3-(benzo[d][1,3] dioxol-5-yl)thiazolidin-4-ones, Letters in Drug Design & Discovery 2017; 14 (9) . https://dx.doi.org/10.2174/1570180814666170106143418

DOI https://dx.doi.org/10.2174/1570180814666170106143418	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X