Background: A new series of aurone-hydrazones have been designed and synthesized in
order to explore new bioactive compounds, which could have potential to be used as active drugs
against Alzheimer’s disease.
Methods: The newly synthesized compounds were characterized by various spectroscopic techniques
(IR, mass spectrometry and NMR spectroscopy) and evaluated in vitro
for their inhibitory potential
against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. All target
compounds exhibited varied degree of IC50
values compared to standard Donepezil. Among the
series, the compound 6c was found as a potent dual inhibitor of AChE and BChE having IC50
0.92±0.01 and 2.25±0.01 μM respectively.
Results and Conclusion: The experimental results were further supported by molecular docking
analysis. Both studies showed that some of these compounds are interesting inhibitors against AChE
and BChE enzymes.