Antitumor Activity of Isosteroidal Alkaloids from the Plants in the Genus Veratrum and Fritillaria

Author(s): Yuanhong Shang, Qingdan Du, Simei Liu, Maksorvor Staadler, Shu Wang, Dongdong Wang*.

Journal Name: Current Protein & Peptide Science

Volume 19 , Issue 3 , 2018

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Abstract:

Isosteroidal alkaloids are a category of promising bioactive compounds which mostly exist in plants of genus Veratrum and Fritillaria. The pharmacological activities of isosteroidal alkaloids include antihypertensive, antitussive, anti-inflammatory, antithrombosis, among others. Recently, some studies show that this kind of alkaloids exhibited significant antitumor activity. To the best of our knowledge, there is no review focusing on their antitumor activity and mechanism of their antitumor activity. To fill the gap, in this review, we summarized antitumor effects of the isosteroidal alkaloids from genus Veratrum and Fritillaria on different tumors and the mechanisms of their antitumor activity. In conclusion, this kind of alkaloids has extensive antitumor activity, and there are several main mechanisms of their antitumor activity, including the Hedgehog signaling pathway, caspase-3 dependent apoptosis, cell cycle, and autophagy.

Keywords: Isosteroidal alkaloids, antitumor activity, Veratrum, Fritillaria, mechanism, traditional chinese medicine.

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Article Details

VOLUME: 19
ISSUE: 3
Year: 2018
Page: [302 - 310]
Pages: 9
DOI: 10.2174/1389203718666170106103747
Price: $65

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