Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery

Title:Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery

Volume: 19 Issue: 3

Author(s): Muhammad Ali Hashmi, Afsar Khan*, Umar Farooq and Sehroon Khan

Affiliation:

• Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060,Pakistan

Keywords: Anticancer, cyclooxygenase, COX-2, alkaloids, enzyme inhibition, anti-inflammatory, anti-tumor.

Abstract: Cancer is the leading cause of death worldwide and anticancer drug discovery is a very hot area of research at present. There are various factors which control and affect cancer, out of which enzymes like cyclooxygenase-2 (COX-2) play a vital role in the growth of tumor cells. Inhibition of this enzyme is a very useful target for the prevention of various types of cancers. Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Different classes of alkaloids including isoquinoline alkaloids, indole alkaloids, piperidine alkaloids, quinazoline alkaloids, and various miscellaneous alkaloids obtained from natural sources have been discussed in detail in this review.

Cite this article as:

Hashmi Ali Muhammad, Khan Afsar*, Farooq Umar and Khan Sehroon, Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery, Current Protein & Peptide Science 2018; 19 (3) . https://dx.doi.org/10.2174/1389203718666170106103031