Exploiting Quorum Sensing Inhibition for the Control of Pseudomonas aeruginosa and Acinetobacter baumannii Biofilms

Author(s): Israel Castillo-Juarez, Luis Esau Lopez-Jacome, Gloria Soberon-Chavez, Maria Tomas, Jintae Lee, Paulina Castaneda-Tamez, Ivan Angelo Hernandez-Barragan, Martha Yumiko Cruz-Muniz, Toshinari Maeda, Thomas K. Wood, Rodolfo Garcia-Contreras*

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 17 , 2017

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Abstract:

Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.

Keywords: Quorum quenching, Homoserine lactone, In vivo biofilm models, Stress response, Resistance.

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Article Details

VOLUME: 17
ISSUE: 17
Year: 2017
Page: [1915 - 1927]
Pages: 13
DOI: 10.2174/1568026617666170105144104
Price: $65

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