Background: Relatively little cancer genome atlas data has been associated with clinically
relevant stratifications of individual cancers.
Results: Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region
set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma,
including a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001).
Conclusion: Roles for CAPCR mutations in cancer progression raise a question about the potential
dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein