Background: We created highly effective ointment on the basis of nanoparticles
of silver and zinc. The ointment contains active nanoingredients that optimize the healing
process. The ointment creates an optimal microenvironment reparative and has antiinflammatory
properties. The drug has a high adsorption capacity; it does not have a local
anti-irritant and allergic effects.
Methods: Silver nanoparticles were prepared by reduction of silver nitrate (AgNO3) with
sodium borohydride (NaBH4) in an aqueous medium in the presence of quaternary ammonium
compounds (QAC). In our research, a nanoparticle ZnO was synthesized by the sol-gel
method. The experiment on the study of the effect of the developed pharmaceutical hydrophilic
ointment compositions on burn healing process behaviour was conducted on Wistar
rats aged 6 months, weighing up to 250 grams in accordance with international requirements
Guide for the Care And Use of Laboratory Animals and the Russian legislation.
Results: As a result of the research, we obtained new pharmaceutical hydrophilic ointment
compositions with different contents of active components, including nanoscale elements
of silver and zinc oxide, which led to a complete recovery of animals in 16-18 days, 6-day
faster than conventional treatments of thermal damage to the skin.
Conclusion: The studies showed that the ointment composition has good regenerating, antioxidant
and wound healing properties due to active proliferation of epithelial tissue in the
wound defect area and complete integumentary structures regeneration. Such effect is ensured
by the additional components of the ointment, such as glycerin and methyl cellulose,
promoting the penetration of active components into the deep panniculus, ensuring the optimal