Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision

Author(s): Nare Sahakyan, Amir Haddad, Shye Richardson, Valery Forcha-Etieundem, Lee Christopher, Hanan Alharbi, Robert Campbell*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 17 , Issue 8 , 2017

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Graphical Abstract:


Nanotechnology has brought about the advent of personalized medicine in the era of targeted therapeutic strategies for cancer therapy. The ability to exploit tumor features for therapeutic gain has made it possible to manufacture more effective nanomedicines for cancer treatment. However, known obstacles, including the inability to overcome pathophysiological barriers of tumors, have impeded disease management. In spite of this, recent efforts have been made to develop more functionalized nanosystems that utilize the active-targeting approach. This article reviews the FDA-approved cancer drug delivery systems in the general framework of personalized nanomedicine. We discuss the latest efforts in the development of functionalized nano-systems, and summarize relevant ongoing preclinical and clinical trials.

Keywords: Personalized medicine, cancer therapy, drug delivery, nanoparticles, tumor-targeted nanomedicines, nanotechnology.

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Article Details

Year: 2017
Page: [1033 - 1039]
Pages: 7
DOI: 10.2174/1871520617666170102150730
Price: $65

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PDF: 58
PRC: 1