In silico Analysis of Toxins of Staphylococcus aureus for Validating Putative Drug Targets

Author(s): Ramadevi Mohana, Subhashree Venugopal*

Journal Name: Infectious Disorders - Drug Targets
(Formerly Current Drug Targets - Infectious Disorders)

Volume 17 , Issue 2 , 2017

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Abstract:

Toxins are one among the numerous virulence factors produced by the bacteria. These are powerful poisonous substances enabling the bacteria to encounter the defense mechanism of human body. The pathogenic system of Staphylococcus aureus is evolved with various exotoxins that cause detrimental effects on human immune system. Four toxins namely enterotoxin A, exfoliative toxin A, TSST-1 and γ-hemolysin were downloaded from Uniprot database and were analyzed to understand the nature of the toxins and for drug target validation. The results inferred that the toxins were found to interact with many protein partners and no homologous sequences for human proteome were found, and based on similarity search in Drugbank, the targets were identified as novel drug targets.

Keywords: Staphylococcus aureus toxins, in silico analysis, drug target validation, BLAST, interactome analysis.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2017
Page: [130 - 142]
Pages: 13
DOI: 10.2174/1871526516666161230150219
Price: $65

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