Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by a lipiddriven,
chronic, low-grade inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused
on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatment targeting the inflammatory
nature of atherosclerosis is still very limited and deserves further attention to fight atherosclerosis
successfully. Here, we review the current development of inflammation and atherosclerosis to discuss novel insights
and potential targets in atherosclerosis, and to address drug discovery based on anti-inflammatory strategy
in atherosclerotic disease.