Background: Carnosol (CS) is an ortho-diphenolic diterpene in rosemary with great
antioxidant potential. This study was designed to investigate the hypolipidemic, anti-oxidant, and
anti-diabetic activities of CS.
Methods: In our experiment, the rats were divided into the following groups of 8 animals each:
control, untreated diabetic, three CS (1, 5, 10 mg/kg/day)-treated diabetic groups. On the first day
of the study, the diabetic groups were given streptozotocin (STZ) in a single intraperitoneal (i.p.)
injection at a dose of 60 mg/kg for induction of diabetes. CS was injected (i.p.) to the treatment
groups from 3 days after STZ administration during a period of 4 weeks. At the end of the
experimental period, we assessed the serum levels of glucose, IL-6, TNF-α, malondialdehyde
(MDA), glutathione–s transferase (GST), superoxide dismutase (SOD), catalase (CAT) activities,
triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), and high density
Results: The results indicated that STZ caused an elevation of serum glucose, IL-6, TNF-α, MDA,
TG, TC, LDL-C, and it also made a reduction of serum GST, SOD, CAT, and HDL-C (p<0.001). The
findings showed amelioration in the serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, GST,
SOD, CAT, and HDL-C in the CS-treated diabetic groups versus the untreated group, in a dose
dependent manner (p < 0.001).
Conclusion: In conclusion, the present investigation proposes that CS may be improved diabetes
and its complications by modulation of oxidative stress and inflammatory responses.