A wide variety of agents have been traditionally used in cardiovascular medicine worldwide and their
precise mechanisms of action have been demonstrated to be largely related to the cardiomyocyte mitochondria
and apoptosis. Abnormalities in the structure and function of the mitochondria and mutations in mitochondrial
DNA can decrease energy production, alter the redox system, impair calcium homeostasis, and induce the mitochondrial
permeability transition pore (MPTP), causing cell death. All of these data provide evidence of mitochondrial
signaling pathways as targets to downregulate cardiac cell apoptosis and thus to prevent and treat cardiovascular
diseases. This review focuses on the protective roles of various agents, mostly natural compounds,
which express beneficial effects on mitochondrial function and suspend the apoptotic signaling mechanisms by
modulating the activity of mitogen-activated protein kinases (MAPKs). Examining cellular and molecular targets
of these agents offers essential experimental information for future pharmacological studies, drug discovery,
clinical trials and applications.
Keywords: Apoptosis, mitochondria, heart, cardioprotection, drugs.
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