Background: Enormous success of antitumor agent cisplatin initiated interest in other
organometallic complexes. A subclass of organometallic compounds termed metallocenes,
characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-)
ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer
Objectives: This review summarizes the progress in the development of organometallic titaniumbased
compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism
of action in relation to potential utilization as anticancer drugs.
Results: Metallocenes bearing titanium as central atom were sorted according to their structure
and modifications and their anticancer activity is further discussed.
Conclusion: Titanocenes represent family of promising compounds exerting cytostatic activity.
We suggest that their application not only as separate agents, but also in combination with newly
developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells
and following utilization in cancer treatment.