Synthesis and Study of Analgesic and Anti-inflammatory Activities of Amide Derivatives of Ibuprofen

Author(s): Abbas Ahmadi*, Mohsen Khalili, Zahra Olama, Shirin Karami, Babak Nahri-Niknafs

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 9 , 2017

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Graphical Abstract:


Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide and represent a mainstay in the therapy of acute and chronic pain and inflammation. The traditional NSAIDs like ibuprofen (I) contain free carboxylic acid group which can produce gastrointestinal (GI) damage for long-term use.

Objective: In order to obtain the novel NSAIDs with less side effects; carboxylic acid moiety has been modified into various amide groups which is the most active area of research in this family.

Method: In this research, synthesis of various pharmacological heterocyclic amides of ibuprofen is described. All the new compounds were tested for their analgesic and anti-inflammatory activities in mice and compared with standard (Ibuprofen) and control (saline) groups.

Results & Conclusion: The results revealed that all the synthesized compounds (III-VI) exhibited more analgesic and anti-inflammatory activities in tail immersion (as a model of acute thermal pain), formalin (as a model of acute chemical and chronic pain) and paw edema (as a model of acute inflammation) tests when compared with standard and control animals. These pharmacological activities were significant for VI compared to other new compounds (III-V) which may be concern to more effective role of morpholin for the reduction of pain and inflammation compared to other used heterocyclic amines.

Keywords: Analgesic, anti-inflammatory, ibuprofen, NSAIDs, pharmacological heterocyclic amides.

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Article Details

Year: 2017
Published on: 15 May, 2017
Page: [799 - 804]
Pages: 6
DOI: 10.2174/1389557516666161226155951
Price: $65

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