Abstract
Background: In vivo bioluminescence imaging has been used extensively for screening assays and for qualitative determination of localization of cells, in particular in cancer studies.
Objective: In this review we show the potential of this noninvasive molecular imaging modality to investigate gene activity, dynamic processes, and translational disease processes, all under true in vivo conditions with the specific focus on brain. Results: We demonstrate a range of applications of bioluminescence imaging in basic and translational neuroscience. Here, emphasis is on the contribution of bioluminescence imaging of the brain to the elucidation of cellular and genetic mechanisms, understanding of dynamic processes, and to the discussion of disease characterization and therapeutic strategies.Keywords: In vivo bioluminescence imaging, neuroscience, dynamic processes, biological cycles, cerebral disease mechanisms, noninvasive molecular imaging.
Current Pharmaceutical Design
Title:Perspectives of In Vivo Bioluminescence Imaging: Application to Basic and Translational Neuroscience
Volume: 23 Issue: 13
Author(s): Stefanie Vogel, Franziska M. Collmann and Mathias Hoehn*
Affiliation:
- In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Gleuelerstrasse 50, D-50931 Cologne,Germany
Keywords: In vivo bioluminescence imaging, neuroscience, dynamic processes, biological cycles, cerebral disease mechanisms, noninvasive molecular imaging.
Abstract: Background: In vivo bioluminescence imaging has been used extensively for screening assays and for qualitative determination of localization of cells, in particular in cancer studies.
Objective: In this review we show the potential of this noninvasive molecular imaging modality to investigate gene activity, dynamic processes, and translational disease processes, all under true in vivo conditions with the specific focus on brain. Results: We demonstrate a range of applications of bioluminescence imaging in basic and translational neuroscience. Here, emphasis is on the contribution of bioluminescence imaging of the brain to the elucidation of cellular and genetic mechanisms, understanding of dynamic processes, and to the discussion of disease characterization and therapeutic strategies.Export Options
About this article
Cite this article as:
Vogel Stefanie, Collmann M. Franziska and Hoehn Mathias*, Perspectives of In Vivo Bioluminescence Imaging: Application to Basic and Translational Neuroscience, Current Pharmaceutical Design 2017; 23 (13) . https://dx.doi.org/10.2174/1381612822666161226151811
DOI https://dx.doi.org/10.2174/1381612822666161226151811 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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