DNA Methylation is Correlated with Pluripotency of Stem Cells

Title:DNA Methylation is Correlated with Pluripotency of Stem Cells

Volume: 12 Issue: 6

Author(s): Ruofeng Wang and Tianqing Li*

Affiliation:

• Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, Yunnan,China

Keywords: Epigenetics, DNA methylation, pluripotent stem cells, naive pluripotent stem cells, primed pluripotent stem cells.

Abstract: Background: Pluripotency of stem cells is an important scientific issue and is attracting great interest for the broader community, especially for regenerative medicine field. Pluripotent stem cells (PSCs) in mammalians are defined as naive- and primed-states according to their cellular, molecular, epigenetic and functional states.

Objective: Understand the correlation between DNA methylation and pluripotency of stem cells.

Method: Based on published papers, we discussed the DNA methylation and corresponding functions for embryonic stem cells. We also summarized the correlation between DNA methylation and naive state maintenance, and outlook future emphasis of DNA methylation for primate naive PSCs.

Results and Conclusion: DNA methylation is closely associated with cell reprogramming, functional remodeling and cell differentiation of PSCs. The pluripotency and naive characteristics of PSCs are closely associated with cell DNA methylation. However, the mechanisms, which are involved in methylation modifications of naive ground, are still one of the important scientific issues for primate naive PSCs because of lack of widely accepted culture condition.

Cite this article as:

Wang Ruofeng and Li Tianqing*, DNA Methylation is Correlated with Pluripotency of Stem Cells, Current Stem Cell Research & Therapy 2017; 12 (6) . https://dx.doi.org/10.2174/1574888X11666161226145432

DOI https://dx.doi.org/10.2174/1574888X11666161226145432	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946