Abstract
Background: Cancer is a complex disease and a huge threat to human health. The prognosis for some cancer types such as breast cancer has improved dramatically over the past 50 years due to rapid development of surgery, chemotherapy and radiotherapy technologies. However, for many patients bearing unresectable cancers, the prognosis remained poor. For this reason, there is always high demand for newer and better therapeutic reagents in cancer field. But the development of anticancer drugs is risky, lengthy and costly. Not many new anticancer reagents come into market every year.
Objective: This review focuses on the latest progress of chemotherapy drug repurposing in cancer research. Conclusion: It is clear from the review of that drug repurposing is faster and cheaper than conventional drug development process. The anticancer efficacy of numerous non-cancer drugs are being tested now. However, not many of them have obtained enough evidence to go into clinical trials for cancer treatment. How to filter the right candidate and narrow the gap between bench and bed remains a hurdle for both conventional and repurposing drug development.Keywords: Drug repurposing, cancer, mechanism, target, signaling pathway, cellular experiments.
Combinatorial Chemistry & High Throughput Screening
Title:Drug Repurposing in Anticancer Reagent Development
Volume: 20 Issue: 5
Author(s): Peng-chen Chen, Xiaolong Liu*Yao Lin*
Affiliation:
- United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, MengchaoHepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian Province, 350025,China
- College of Life Sciences, Qishan Campus, Fujian Normal University, Fuzhou, Fujian Province, 350117,China
Keywords: Drug repurposing, cancer, mechanism, target, signaling pathway, cellular experiments.
Abstract: Background: Cancer is a complex disease and a huge threat to human health. The prognosis for some cancer types such as breast cancer has improved dramatically over the past 50 years due to rapid development of surgery, chemotherapy and radiotherapy technologies. However, for many patients bearing unresectable cancers, the prognosis remained poor. For this reason, there is always high demand for newer and better therapeutic reagents in cancer field. But the development of anticancer drugs is risky, lengthy and costly. Not many new anticancer reagents come into market every year.
Objective: This review focuses on the latest progress of chemotherapy drug repurposing in cancer research. Conclusion: It is clear from the review of that drug repurposing is faster and cheaper than conventional drug development process. The anticancer efficacy of numerous non-cancer drugs are being tested now. However, not many of them have obtained enough evidence to go into clinical trials for cancer treatment. How to filter the right candidate and narrow the gap between bench and bed remains a hurdle for both conventional and repurposing drug development.Export Options
About this article
Cite this article as:
Chen Peng-chen, Liu Xiaolong*, Lin Yao*, Drug Repurposing in Anticancer Reagent Development, Combinatorial Chemistry & High Throughput Screening 2017; 20 (5) . https://dx.doi.org/10.2174/1386207319666161226143424
DOI https://dx.doi.org/10.2174/1386207319666161226143424 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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