Sumoylation is a reversible post-translational modification that
conjugates small peptide SUMO (small ubiquitin-like modifier) to a target
protein. Global protein sumoylation and expression of components in
sumoylation pathway were recently found to be altered in the process of
organismal aging. In addition, key factors controlling cellular senescence are
known to be sumoylated. This review will summarize current information on
the function of sumoylation in cellular senescence and aging.
Keywords: Sumoylation, p53, RB, senescence, aging.
Rights & PermissionsPrintExport