Background: Successful delivery of therapeutic agents in the brain is very challenging,
which makes treatment of various brain disorders very difficult. One of the major causes of this difficulty
is the presence of physiological barriers in the brain like blood brain barrier (BBB) and blood
cerebrospinal fluid (CSF) barrier. These barriers are very specific and restrict the entry of water soluble
agents and ionized molecule.
Objective: The current article focuses on the transcranial route, transcranial focused ultrasound
(FUS), and the techniques involved in transcranial focused ultrasound (FUS) delivery and recent updates
of this system.
Results: The study describes that the FUS in conjunction with various other techniques opens the
BBB very effectively.
Conclusion: The administration of therapeutic agent using various FUS techniques opens a new perspective
in treating CNS diseases.