Abstract
In nano drug formulations the mechanism of release is a critical process to recognize controlled and targeted drug delivery systems. In order to gain high bioavailability and specificity from the drug to reach its therapeutic goal, the active substance must be loaded into the nanoparticles efficiently. Therefore, the amount in biological fluids or tissues and the remaining amount in nano carriers are very important parameters to understand the potential of the nano drug delivery systems. For this aim, suitable and validated quantitation methods are required to determine released drug concentrations from nano pharmaceutical formulations.
HPLC (High Performance Liquid Chromatography) is one of the most common techniques used for determination of released drug content out of nano drug formulations, in different physical conditions, over different periods of time. Since there are many types of HPLC methods depending on detector and column types, it is a challenge for the researchers to choose a suitable method that is simple, fast and validated HPLC techniques for their nano drug delivery systems. This review’s goal is to compare HPLC methods that are currently used in different nano drug delivery systems in order to provide detailed and useful information for researchers.Keywords: HPLC, Nano Drug delivery systems, Nano carriers, Drug release, Biological fluids, Pharmaceutical preparations.
Current Topics in Medicinal Chemistry
Title:Current HPLC Methods for Assay of Nano Drug Delivery Systems
Volume: 17 Issue: 13
Author(s): Serife Evrim Kepekci Tekkeli*Mustafa Volkan Kiziltas
Affiliation:
- Department of Analytical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, P.O. Box: 34093, Istanbul,Turkey
Keywords: HPLC, Nano Drug delivery systems, Nano carriers, Drug release, Biological fluids, Pharmaceutical preparations.
Abstract: In nano drug formulations the mechanism of release is a critical process to recognize controlled and targeted drug delivery systems. In order to gain high bioavailability and specificity from the drug to reach its therapeutic goal, the active substance must be loaded into the nanoparticles efficiently. Therefore, the amount in biological fluids or tissues and the remaining amount in nano carriers are very important parameters to understand the potential of the nano drug delivery systems. For this aim, suitable and validated quantitation methods are required to determine released drug concentrations from nano pharmaceutical formulations.
HPLC (High Performance Liquid Chromatography) is one of the most common techniques used for determination of released drug content out of nano drug formulations, in different physical conditions, over different periods of time. Since there are many types of HPLC methods depending on detector and column types, it is a challenge for the researchers to choose a suitable method that is simple, fast and validated HPLC techniques for their nano drug delivery systems. This review’s goal is to compare HPLC methods that are currently used in different nano drug delivery systems in order to provide detailed and useful information for researchers.Export Options
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Cite this article as:
Tekkeli Evrim Kepekci Serife*, Kiziltas Volkan Mustafa, Current HPLC Methods for Assay of Nano Drug Delivery Systems, Current Topics in Medicinal Chemistry 2017; 17 (13) . https://dx.doi.org/10.2174/1568026616666161222112305
DOI https://dx.doi.org/10.2174/1568026616666161222112305 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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