Target Recognition Molecules and Molecular Modeling Studies

Author(s): Burcu Culhaoglu, Atilla Akdemir*

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 13 , 2017

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Graphical Abstract:


Targeted delivery systems aim to deliver drugs to their intended site of action and as such they are expected to show more desired effects and less unwanted effects. The system itself is composed of a vesicle-encapsulated drug with “target recognition molecules” on the envelop. Ideally, these target recognition molecules, being either small non-peptidic molecules or peptides, are basically high-affinity ligands for a receptor or other protein that is expressed specifically and at high concentrations on the target cells. This review will focus on several widely used examples of target recognition molecules and on how molecular modelling studies have been used in the development of nano drug carrier systems in general.

Keywords: Targeted drug delivery, Nano drug delivery systems, Docking, Molecular dynamics, Central nervous system, Cell penetrating peptides.

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Article Details

Year: 2017
Page: [1580 - 1587]
Pages: 8
DOI: 10.2174/1568026616666161222100702
Price: $65

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