Guide of Hypertensive Crisis Pharmacotherapy

Author(s): Priyanka Wani-Parekh*, Carlos Blanco-Garcia, Melissa Mendez, Debabrata Mukherjee

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 17 , Issue 1 , 2017

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Graphical Abstract:


Background: Cardiovascular diseases (CVD) are the number one cause of death globally compared to any other cause. CVD accounts for approximately 17.3 million deaths per year and are rising. Hypertension is the leading risk factor for cardiovascular diseases. Approximately, 80 million people suffer from hypertension in the U.S. While, majority of these individuals are on antihypertensive medications only 54% of individuals with hypertension are optimally controlled. Heart failure and stroke are some of the devastating complications of uncontrolled hypertension. Hypertensive crisis can be classified as either an urgency or emergency; difference between the two is the presence of end organ damage, which is noted in hypertensive emergency. Hypertensive crisis is usually treated by parenteral antihypertensive medications. The main drug classes of drugs for treatment are nitrates, calcium channel blockers, dopamine-1 agonists, adrenergic-blocking agents etc.

Conclusion: In this review, we discuss approach to management of hypertensive crisis and each drug class with its physiology and complications.

Keywords: Hypertensive emergency, cardiovascular disease, antihypertensive medications, pregnancy, eclampsia.

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Article Details

Year: 2017
Published on: 20 December, 2016
Page: [52 - 57]
Pages: 6
DOI: 10.2174/1871529X16666161220142020
Price: $65

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